El聽Premio Primetime Emmy a la Mejor Actriz en Serie de Comedia es un galard贸n otorgado por la Academia de Artes y Ciencias de la Televisi贸n en reconocimiento a la mejor actuaci贸n por un actriz principal en una comedia televisiva.
| A帽o | Actriz | Programa |
| 2025 | Jean Smart | Hacks (HBO Max) |
| 2024 | Jean Smart | Hacks (HBO Max) |
| 2023 | Quinta Brunson | Abbott Elementary (ABC) |
| 2022 | Jean Smart | Hacks (HBO Max) |
| 2021 | Jean Smart | Hacks (HBO Max) |
| 2020 | Catherine O鈥橦ara | Schitt鈥檚 Creek (Pop TV) |
| 2019 | Phoebe Waller-Bridge | Fleabag (Amazon) |
| 2018 | Rachel Brosnahan | The Marvelous Mrs. Maisel (Amazon) |
| 2017 | Julia Louis-Dreyfus | Veep (HBO) |
| 2016 | Julia Louis-Dreyfus | Veep (HBO) |
| 2015 | Julia Louis-Dreyfus | Veep (HBO) |
| 2014 | Julia Louis-Dreyfus | Veep (HBO) |
| 2013 | Julia Louis-Dreyfus | Veep (HBO) |
| 2012 | Julia Louis-Dreyfus | Veep (HBO) |
| 2011 | Melissa McCarthy | Mike & Molly (CBS) |
| 2010 | Edie Falco | Nurse Jackie (Showtime) |
| 2009 | Toni Collette | United States of Tara (Showtime) |
| 2008 | Tina Fey | 30 Rock (NBC) |
| 2007 | America Ferrera | Ugly Betty (ABC) |
| 2006 | Julia Louis-Dreyfus | The New Adventures of Old Christine (CBS) |
| 2005 | Felicity Huffman | Desperate Housewives (ABC) |
| 2004 | Sarah Jessica Parker | Sex and the City (HBO) |
| 2003 | Debra Messing | Will & Grace (NBC) |
| 2002 | Jennifer Aniston | Friends (NBC) |
| 2001 | Patricia Heaton | Everybody Loves Raymond (CBS) |
| 2000 | Patricia Heaton | Everybody Loves Raymond (CBS) |
| 1999 | Helen Hunt | Mad About You (NBC) |
| 1998 | Helen Hunt | Mad About You (NBC) |
| 1997 | Helen Hunt | Mad About You (NBC) |
| 1996 | Helen Hunt | Mad About You (NBC) |
| 1995 | Candice Bergen | Murphy Brown (CBS) |
| 1994 | Candice Bergen | Murphy Brown (CBS) |
| 1993 | Roseanne Arnold | Roseanne (ABC) |
| 1992 | Candice Bergen | Murphy Brown (CBS) |
| 1991 | Kristie Alley | Cheers (NBC) |
| 1990 | Candice Bergen | Murphy Brown (CBS) |
| 1989 | Candice Bergen | Murphy Brown (CBS) |
| 1988 | Beatrice Arthur | The Golden Girls (NBC) |
| 1987 | Rue McClanahan | The Golden Girls (NBC) |
| 1986 | Betty White | The Golden Girls (NBC) |
| 1985 | Jane Curtin | Kate & Allie (CBS) |
| 1984 | Jane Curtin | Kate & Allie (CBS) |
| 1983 | Shelly Long | Cheers (NBC) |
| 1982 | Carol Kane | Taxi (ABC) |
| 1981 | Isabel Sanford | The Jefferson (CBS) |
| 1980 | Cathryb Damon | Soap (ABC) |
| 1979 | Ruth Gordon | Taxi (ABC) |
| 1978 | Jean Stapleton | All in the Family (CBS) |
| 1977 | Beatrice Arthur | Maude (CBS) |
| 1976 | Mary Tyler Moore | The Mary Tyler Moore Show (CBS) |
| 1975 | Valerie Harper | Rhoda (CBS) |
| 1974 | Mary Tyler Moore | The Mary Tyler Moore Show (CBS) |
| 1973 | Mary Tyler Moore | The Mary Tyler Moore Show (CBS) |
| 1972 | Jean Stapleton | All in the Family (CBS) |
| 1971 | Jean Stapleton | All in the Family (CBS) |
| 1970 | Hope Lange | The Ghost & Mrs Muir (NBC) |
| 1969 | Hope Lange | The Ghost & Mrs Muir (NBC) |
| 1968 | Lucille Ball | The Lucy Show (CBS) |
| 1967 | Lucille Ball | The Lucy Show (CBS) |
| 1966 | Mary Tyler Moore | The Dick Van Dyke Show (CBS) |
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