El Premio Primetime Emmy a la Mejor Actriz en Serie Dramática es un galardón otorgado por la Academia de Artes y Ciencias de la Televisión en reconocimiento a la mejor actuación por un actriz principal en una serie dramática.
| Año | Actriz | Programa |
| 2025 | TBA | TBA |
| 2024 | Anna Sawai | Shogun (FX) |
| 2023 | Sarah Snook | Succession (HBO) |
| 2022 | Zendaya | Euphoria (HBO) |
| 2021 | Olivia Colman | The Crown (Netflix) |
| 2020 | Zendaya | Euphoria (HBO) |
| 2019 | Jodie Comer | Killing Eve (BBC) |
| 2018 | Claire Foy | The Crown (Netflix) |
| 2017 | Elisabeth Moss | The Handmaid’s Tale (Hulu) |
| 2016 | Tatiana Maslany | Orphan Black (BBC) |
| 2015 | Viola Davis | How to Get Away with Murder (ABC) |
| 2014 | Julianna Margulies | The Good Wife (CBS) |
| 2013 | Claire Danes | Homeland (Showtime) |
| 2012 | Claire Danes | Homeland (Showtime) |
| 2011 | Julianna Margulies | The Good Wife (CBS) |
| 2010 | Kyra Sedgwick | The Closer (TNT) |
| 2009 | Glenn Close | Damages (FX) |
| 2008 | Glenn Close | Damages (FX) |
| 2007 | Sally Field | Brothers & Sisters (ABC) |
| 2006 | Mariska Hargitay | Law & Order: Special Victims Unit (NBC) |
| 2005 | Patricia Arquette | Medium (NBC) |
| 2004 | Allison Janney | The West Wing (NBC) |
| 2003 | Edie Falco | The Sopranos (HBO) |
| 2002 | Allison Janney | The West Wing (NBC) |
| 2001 | Edie Falco | The Sopranos (HBO) |
| 2000 | Sela Ward | Once and Again (ABC) |
| 1999 | Edie Falco | The Sopranos (HBO) |
| 1998 | Christine Lahti | Chicago Hope (CBS) |
| 1997 | Gillian Anderson | The X-Files (Fox) |
| 1996 | Kathy Baker | Picket Fences (CBS) |
| 1995 | Kathy Baker | Picket Fences (CBS) |
| 1994 | Sela Ward | Sisters (NBC) |
| 1993 | Kathy Baker | Picket Fences (CBS) |
| 1992 | Dana Delany | China Beach (ABC) |
| 1991 | Patricia Wettig | Thirtysomething (ABC) |
| 1990 | Patricia Wettig | Thirtysomething (ABC) |
| 1989 | Dana Delany | China Beach (ABC) |
| 1988 | Tyne Daly | Cagney & Lacey (CBS) |
| 1987 | Sharon Gless | Cagney & Lacey (CBS) |
| 1986 | Sharon Gless | Cagney & Lacey (CBS) |
| 1985 | Tyne Daly | Cagney & Lacey (CBS) |
| 1984 | Tyne Daly | Cagney & Lacey (CBS) |
| 1983 | Tyne Daly | Cagney & Lacey (CBS) |
| 1982 | Michael Learned | Nurse (CBS) |
| 1981 | Barbara Babcock | Hill Street Blues (NBC) |
| 1980 | Barbara Bel Geddes | Dallas (CBS) |
| 1979 | Mariette Hartley | The Incredible Hulk (CBS) |
| 1978 | Sada Thompson | Family (ABC) |
| 1977 | Lindsay Wagner | The Bionic Woman (ABC) |
| 1976 | Michael Learned | The Waltons (CBS) |
| 1975 | Jean Marsh | Upstairs, Downstairs (PBS) |
| 1974 | Michael Learned | The Waltons (CBS) |
| 1973 | Michael Learned | The Waltons (CBS) |
| 1972 | Glenda Jackson | Elizabeth R (PBS) |
| 1971 | Susan Hampshire | The First Churchills (PBS) |
| 1970 | Susan Hampshire | The Forsyte Saga (NET) |
| 1969 | Barbara Bain | Mission: Impossible (CBS) |
| 1968 | Barbara Bain | Mission: Impossible (CBS) |
| 1967 | Barbara Bain | Mission: Impossible (CBS) |
| 1966 | Barbara Stanwyck | The Big Valley (ABC) |