El Premio Primetime Emmy al Mejor Actor en Serie de Comedia es un galard贸n otorgado por la Academia de Artes y Ciencias de la Televisi贸n en reconocimiento a la mejor actuaci贸n por un actor principal en una comedia televisiva.
| A帽o | Ganadores | Programa |
| 2025 | Seth Rogen | The Studio (Apple TV+) |
| 2024 | Jeremy Allen White | The Bear (FX) |
| 2023 | Jeremy Allen White | The Bear (FX) |
| 2022 | Jason Sudeikis | Ted Lasso (Apple TV) |
| 2021 | Jason Sudeikis | Ted Lasso (Apple TV) |
| 2020 | Eugene Levy | Schitt鈥檚 Creek (Pop TV) |
| 2019 | Bill Hader | Barry (HBO) |
| 2018 | Bill Hader | Barry (HBO) |
| 2017 | Donald Glover | Atlanta (FX) |
| 2016 | Jeffrey Tambor | Transparent (Amazon) |
| 2015 | Jeffrey Tambor | Transparent (Amazon) |
| 2014 | Jim Parsons | The Big Bang Theory (CBS) |
| 2013 | Jim Parsons | The Big Bang Theory (CBS) |
| 2012 | Jon Cryer | Two and a Half Men (CBS) |
| 2011 | Jim Parsons | The Big Bang Theory (CBS) |
| 2010 | Jim Parsons | The Big Bang Theory (CBS) |
| 2009 | Alec Baldwin | 30 Rock (NBC) |
| 2008 | Alec Baldwin | 30 Rock (NBC) |
| 2007 | Ricky Gervais | Extras (HBO) |
| 2006 | Tony Shalhoub | Monk (USA) |
| 2005 | Tony Shalhoub | Monk (USA) |
| 2004 | Kelsey Grammer | Frasier (NBC) |
| 2003 | Tony Shalhoub | Monk (USA) |
| 2002 | Ray Romano | Everybody Loves Raymond (CBS) |
| 2001 | Eric McCormack | Will & Grace (NBC) |
| 2000 | Michael J. Fox | Spin City (ABC) |
| 1999 | John Lithgow | 3rd Rock from the Sun (NBC) |
| 1998 | Kelsey Grammer | Frasier (NBC) |
| 1997 | John Lithgow | 3rd Rock from the Sun (NBC) |
| 1996 | John Lithgow | 3rd Rock from the Sun (NBC) |
| 1995 | Kelsey Grammer | Frasier (NBC) |
| 1994 | Kelsey Grammer | Frasier (NBC) |
| 1993 | Ted Danson | Cheers (NBC) |
| 1992 | Craig T. Nelson | Coach (ABC) |
| 1991 | Burt Reynolds | Evening Shade (CBS) |
| 1990 | Ted Danson | Cheers (NBC) |
| 1989 | Richard Mulligan | Empty Nest (NBC) |
| 1988 | Michael J. Fox | Family Ties (NBC) |
| 1987 | Michael J. Fox | Family Ties (NBC) |
| 1986 | Michael J. Fox | Family Ties聽 (NBC) |
| 1985 | Robert Guillaume | Benson (ABC) |
| 1984 | John Ritter | Three鈥檚 Company (ABC) |
| 1983 | Judd Hirsch | Taxi (NBC) |
| 1982 | Alan Alda | MASH (CBS) |
| 1981 | Judd Hirsch | Taxi (ABC) |
| 1980 | Richard Mulligan | Soap (ABC) |
| 1979 | Carroll O鈥機onnor | All in the Family (CBS) |
| 1978 | Carroll O鈥機onnor | All in the Family (CBS) |
| 1977 | Carroll O鈥機onnor | All in the Family (CBS) |
| 1976 | Jack Albertson | Chico and the Man (NBC) |
| 1975 | Tony Randall | The Odd Couple (ABC) |
| 1974 | Alan Alda | MASH (CBS) |
| 1973 | Jack Klugman | The Odd Couple (ABC) |
| 1972 | Carroll O鈥機onnor | All in the Family聽 (CBS) |
| 1971 | Jack Klugman | The Odd Couple (ABC) |
| 1970 | William Windom | My World and Welcome to It (NBC) |
| 1969 | Don Adams | Get Smart (NBC) |
| 1968 | Don Adams | Get Smart (NBC) |
| 1967 | Don Adams | Get Smart (NBC) |
| 1966 | Dick Van Dyke | The Dick Van Dyke Show (CBS) |
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